Article

A New Approach for Discovering Functional Links Connecting Non-Coding Regulatory Variants to Gene Targets

2024-06-14

Abstract excerpt

Genome-wide association studies (GWAS) have linked thousands of genetic variants to various complex traits or diseases. However, most identified variants have weak individual effects, are correlated with nearby polymorphisms due to linkage disequilibrium (LD), and are located in non-coding cis-regulatory elements (CREs). These characteristics complicate the assessment of the direct impact of each variant on tissue...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2295a21b-e1d2-5a37-a2a2-c76d14fd429b
DOI: 10.1101/2024.06.13.598913

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A New Approach for Discovering Functional Links Connecting Non-Coding Regulatory Variants to Gene TargetsDOI 10.1101/2024.06.13.598913Read

Endogenous fine-mapping of functional regulatory elements in complex genetic lociSemantic proximity Read

Multiple causal variants underlie genetic associations in humans.Semantic proximity Read

Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions.Semantic proximity Read

Screening for functional regulatory variants in open chromatin using GenIE-ATACSemantic proximity Read

Predicting target genes of non-coding regulatory variants with IRT.Semantic proximity Read

Genomic approaches for understanding the genetics of complex disease.Semantic proximity Read

Mapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning.Semantic proximity Read

Interpreting noncoding genetic variation in complex traits and human disease.Semantic proximity Read

Regulatory landscape enrichment analysis (RLEA): a computational toolkit for non-coding variant enrichment and cell type prioritization.Semantic proximity Read

SNPnotes: high-throughput tissue-specific functional annotation of single nucleotide variantsSemantic proximity Read

High resolution genetic mapping of causal regulatory interactions in the human genomeSemantic proximity Read

Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases.Semantic proximity Read