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Article

O-GlcNAc transferase suppresses necroptosis and liver fibrosis

2019-01-14

Abstract excerpt

Over a billion people suffer from chronic liver diseases worldwide, which often leads to fibrosis and then cirrhosis. Treatments for fibrosis remain experimental, in part because no unifying mechanism has been identified that initiates liver fibrosis. Here we report that O-linked β-N-acetylglucosamine (O-GlcNAc) modification protects against hepatocyte necroptosis and initiation of liver fibrosis. Decreased O-GlcN...

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Literature Corpus work
1efefec8-ce04-5100-bf09-c3a2f3fa728e
DOI
10.1101/519975
Open publication

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O-GlcNAc transferase suppresses necroptosis and liver fibrosisDOI 10.1101/519975
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