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Article

The role of inflammation induced by necroptosis in the development of fibrosis and liver cancer in novel knockin mouse models fed a western diet

8 Nov 2024

Abstract excerpt

Non-resolving, chronic inflammation (inflammaging) is believed to play an important role in aging and age-related diseases. The goal of this study was to determine if inflammation induced by necroptosis arising from the liver plays a role in chronic liver disease (CLD) and liver cancer in mice fed a western diet (WD). Necroptosis was induced in liver using two knockin (KI) mouse models that overexpress genes...

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PMID: 39514172
DOI: 10.1007/s11357-024-01418-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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