Article
Alpha-1 antitrypsin governs alcohol-related liver disease in mice and humans.
Gut - 1 Mar 2021
Grander Christoph, Schaefer Benedikt, Schwärzler Julian, Grabherr Felix, de Graaf Dennis M, Enrich Barbara, Oberhuber Georg, Mayr Lisa, Sangineto Moris, Jaschke Nikolai, Adolph Timon E, Effenberger Maria, Moschen Alexander R, Dinarello Charles A, Zoller Heinz, Tilg Herbert
Abstract excerpt
OBJECTIVE: Alcohol-related liver disease (ALD) is a global healthcare problem with limited treatment options. Alpha-1 antitrypsin (AAT, encoded by SERPINA1) shows potent anti-inflammatory activities in many preclinical and clinical trials. In our study, we aimed to explore the role of AAT in ALD. DESIGN: An unselected cohort of 512 patients with cirrhosis was clinically characterised. Survival, clinical and...
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