Article

FTO O-GlcNAcylation downregulates NLRP3 inflammasome and pyroptosis in macrophages

2025-03-20

Abstract excerpt

<title>Abstract</title> <p>The fat mass and obesity-associated protein (FTO), a key RNA N6-methyladenosine (m6A) demethylase, has recently emerged as a significant regulator of inflammatory response. However, the specific role and underlying mechanisms of FTO, especially FTO O-GlcNAcylation, in inflammation remain elusive. Here we report a mechanism that O-GlcNAcylation modification controls the biological functi...

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Literature Corpus work: 37d76dc8-d2df-52a8-9765-8709772a5c25
DOI: 10.21203/rs.3.rs-5654474/v1

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