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Endothelial <i>GATA6</i> deficiency suppresses intracellular TLR3-interferon signaling in HPAECs and promotes interferon response in HPASMCs

2025-12-11

Abstract excerpt

GATA6 is a key transcription factor crucial for maintaining endothelial cell (EC) homeostasis. The dysregulation of endothelial immune function is a central feature in diseases such as pulmonary arterial hypertension (PAH). In this study, we explored the consequences of GATA6 deficiency in human pulmonary arterial endothelial cells (HPAECs) and its impact on immune response pathways. We report that siRNA-induced...

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Literature Corpus work
1ecd2927-24a0-50a1-a3ac-4f975093ece5
DOI
10.64898/2025.12.09.693063
Open publication

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Endothelial <i>GATA6</i> deficiency suppresses intracellular TLR3-interferon signaling in HPAECs and promotes interferon response in HPASMCsDOI 10.64898/2025.12.09.693063
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