Article

STING contributes to pulmonary hypertension by targeting the interferon and BMPR2 signaling through targeting F2RL3

2024-02-21

Abstract excerpt

<h4>Rational/Objectives</h4> Pulmonary hypertension (PH) is an incurable disease characterized by pulmonary arterial remodeling. Endothelial injury and inflammation are the key triggers of the disease initiation. Recent findings suggest that STING (stimulator of interferon genes) activation plays a critical role in the endothelial dysfunction and interferon signaling. Here, we investigated the involvement of STIN...

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Literature Corpus work: 2b264f03-d163-52a1-90fd-374c701c941b
DOI: 10.1101/2024.02.20.578386

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