Article
KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension.
Communications biology - 15 Jun 2026
Alharbi Rehab, Keles Merve, Fernandes Nadia, Maude Hannah, Fellows Adam, Williams Richard D, Chen Chien-Nien, Lambie Nathalie, Matthews Nik, Al-Sahaf May, Barnett Sam N, Guo Minzhe, Zhao Lan, Lawrie Allan, Whitsett Jeffrey A, Cebola Inês, Wojciak-Stothard Beata
Abstract excerpt
Pulmonary arterial hypertension (PAH) is a severe, currently incurable lung disease characterized by endothelial injury and excessive repair, leading to arterial narrowing. However, the contributory mechanisms remain poorly understood. Here we show that Krüppel-like factor 6 (KLF6) is a feature of vascular pathology in PAH. KLF6 expression is elevated in human PAH and preclinical models of PAH and promotes...
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