Article

Targeting IL-6-STAT3/STAT4 Signaling Restores FOXP3 Expression in Pulmonary Arterial Endothelium and Reveals Novel Biomarkers for PAH

2026-05-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Interleukin-6 (IL-6) is a central driver of pulmonary vascular remodeling in idiopathic, heritable, and connective tissue disease-associated pulmonary arterial hypertension (PAH). Elevated IL-6 correlates with right ventricular (RV) dysfunction and poor survival. However, the specific downstream mechanisms by which IL-6 drives pathogenesis remain poorly defined. We investiga...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f9862da0-b996-5546-9f74-5015eb55234b
DOI: 10.64898/2026.04.29.721729

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting IL-6-STAT3/STAT4 Signaling Restores FOXP3 Expression in Pulmonary Arterial Endothelium and Reveals Novel Biomarkers for PAHDOI 10.64898/2026.04.29.721729Read

Restoration of Foxp3+ Regulatory T Cells by HDAC-Dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension PathologySemantic proximity Read

The Interplay Between IL-6, Hepcidin, and BMPR2 Signalling in Pulmonary Arterial Hypertension: Mechanistic Insights into Vascular RemodellingSemantic proximity Read

Identification of immune‐associated signatures and potential therapeutic targets for pulmonary arterial hypertensionSemantic proximity Read

Sotatercept Reverses SIN3a Deficiency-Driven PAH by Reprogramming BMPR2/TGF-β-HIF-1α Signaling PathwaysSemantic proximity Read

Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection FractionSemantic proximity Read

STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3Semantic proximity Read

IL-11 is a therapeutic target in idiopathic pulmonary fibrosisSemantic proximity Read

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension VasculopathySemantic proximity Read

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.Semantic proximity Read

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and FoeSemantic proximity Read

Role of Interleukin-6 in Rheumatoid Arthritis-Associated Interstitial Lung Disease: Focus on the JAK/STAT Pathway and Macrophage PolarizationSemantic proximity Read

PCSK6 and Survival in Idiopathic Pulmonary FibrosisSemantic proximity Read