Article

Enhancer architecture sensitizes cell specific responses to <i>Notch</i> gene dose via a bind and discard mechanism

2019-08-22

Abstract excerpt

<h4>SUMMARY</h4> Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we show that inserting a single enhancer containing pioneer transcription factor sites coupled to Notch dimer sites can unexpectedly induce a subset of Drosophila Notch haploinsufficien...

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Literature Corpus work: 1ec85e72-02b3-55de-b2ad-fb30c6be8b29
DOI: 10.1101/742908

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