Article

Interplay between copy number, dosage compensation and expression noise in <i>Drosophila</i>

2016-02-23

Abstract excerpt

Gene copy number variations are associated with many disorders characterized by high phenotypic heterogeneity. Disease penetrance differs even in genetically identical twins. Can such heterogeneity arise, in part, from increased expression variability of one dose genes? While increased variability in the context of single cell gene expression is well recognized, our computational simulations indicated that in a mu...

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Identifiers and source

Literature Corpus work: 1dec132b-8cf3-5954-873e-e8cc4960f97c
DOI: 10.1101/041038

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