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Article

Chromatin modification of Notch targets in olfactory receptor neuron diversification.

Nature neuroscience - 25 Dec 2011

Endo Keita, Karim M Rezaul, Taniguchi Hiroaki, Krejci Alena, Kinameri Emi, Siebert Matthias, Ito Kei, Bray Sarah J, Moore Adrian W

Abstract excerpt

Neuronal-class diversification is central during neurogenesis. This requirement is exemplified in the olfactory system, which utilizes a large array of olfactory receptor neuron (ORN) classes. We discovered an epigenetic mechanism in which neuron diversity is maximized via locus-specific chromatin modifications that generate context-dependent responses from a single, generally used intracellular signal. Each ORN...

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PMID: 22197833
DOI: 10.1038/nn.2998

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