Article
Interpreting clone-mediated perturbations of morphogen profiles.
Developmental biology - 1 Feb 2005
Eldar Avigdor, Barkai Naama
Abstract excerpt
Generating clones of mutated cells within a wild-type tissue is a powerful experimental paradigm for elucidating gene function. Recently, this approach was employed for identifying genes that shape morphogen profiles in the Drosophila wing-imaginal disc. Interpreting such experiments poses a theoretical challenge. We present a general framework that links specific features of the morphogen profile in the clone...
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