Article
Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism.
eLife - 16 Apr 2020
Kuang Yi, Golan Ohad, Preusse Kristina, Cain Brittany, Christensen Collin J, Salomone Joseph, Campbell Ian, Okwubido-Williams FearGod V, Hass Matthew R, Yuan Zhenyu, Eafergan Nathanel, Moberg Kenneth H, Kovall Rhett A, Kopan Raphael, Sprinzak David, Gebelein Brian
Abstract excerpt
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found that inserting an enhancer containing pioneer transcription factor sites coupled to Notch dimer sites can induce a subset of Notch haploinsufficiency phenotypes in Drosophila with...
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