Article

Intrinsically disordered N-terminal regions suppress cotranslational protein degradation

2026-06-13

Abstract excerpt

Intrinsically disordered regions (IDRs) of proteins are thought to be inherently sensitive to proteolysis and considered one of the key components constituting an efficient degron. Here we report that IDRs can also suppress protein degradation. Our recent study showed that yeast ribosomal proteins, while posttranslationally stable, are subject to cotranslational protein degradation (CTPD). In mapping the degron re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ec74def-9c37-5ee4-ab71-a13b00a2f5fc
DOI: 10.64898/2026.06.13.732044

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intrinsically disordered N-terminal regions suppress cotranslational protein degradationDOI 10.64898/2026.06.13.732044Read

Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark MatterSemantic proximity Read

Exploring Intrinsic Disorder in Stress Granules Proteome: Implications for Structure-Function Dynamics and Pathological AggregationSemantic proximity Read

Signal Recognition Particle in Human DiseasesSemantic proximity Read

Eukaryotic ribosome quality control system: a potential therapeutic target for human diseasesSemantic proximity Read

Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseaseSemantic proximity Read

A 'distributed degron' allows regulated entry into the ER degradation pathway.Semantic proximity Read

Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery.Semantic proximity Read

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteinsSemantic proximity Read

Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR proteinSemantic proximity Read

ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis IntermediatesSemantic proximity Read

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.Semantic proximity Read

Disorders of protein biogenesis and stability.Semantic proximity Read