Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Signal Recognition Particle in Human Diseases

8 Jun 2022

Abstract excerpt

The signal recognition particle (SRP) is a ribonucleoprotein complex with dual functions. It co-translationally targets proteins with a signal sequence to the endoplasmic reticulum (ER) and protects their mRNA from degradation. If SRP is depleted or cannot recognize the signal sequence, then the Regulation of Aberrant Protein Production (RAPP) is activated, which results in the loss of secretory protein mRNA. If...

Source

Identifiers

PMID: 35754847
DOI: 10.3389/fgene.2022.898083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal Recognition Particle in Human DiseasesPMID 35754847Read ↗

Translational Control of Secretory Proteins in Health and Disease.Semantic proximity Read ↗

Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease.Semantic proximity Read ↗

Eukaryotic ribosome quality control system: a potential therapeutic target for human diseasesSemantic proximity Read ↗

Disorders of protein biogenesis and stability.Semantic proximity Read ↗

Hypo- and Hyper-Assembly Diseases of RNA-Protein Complexes.Semantic proximity Read ↗

Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?Semantic proximity Read ↗

Pathogenic Signal Sequence Mutations in Progranulin Disrupt SRP Interactions Required for mRNA Stability.Semantic proximity Read ↗

Defective Ribonucleoproteins, Mistakes in RNA Processing, and Diseases.Semantic proximity Read ↗

SKI complex: A multifaceted cytoplasmic RNA exosome cofactor in mRNA metabolism with links to disease, developmental processes, and antiviral responsesSemantic proximity Read ↗

Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changesSemantic proximity Read ↗

The double whammy of ER-retention and dominant-negative effects in numerous autosomal dominant diseases: significance in disease mechanisms and therapy.Semantic proximity Read ↗

When ribosomes go bad: diseases of ribosome biogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.