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A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

23 Aug 2016

Abstract excerpt

Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1. tom1 cells show reduced ubiquitination of multiple RPs, exceptional accumulation of detergent-insoluble proteins including multiple RPs, and hypersensitivity to...

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PMID: 27552055
DOI: 10.7554/elife.19105

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