Article

Exploring Intrinsic Disorder in Stress Granules Proteome: Implications for Structure-Function Dynamics and Pathological Aggregation

2024-08-23

Abstract excerpt

<title>Abstract</title> <p>Prolonged cellular stress causes the formation of small physiological stress granules (SGs) that gradually accumulate due to chronic stress or mutations in RNA-binding proteins and form aggregations in diseased brains with progressive, age-related impairment of proteasomal and autophagic systems. These aggregations are a consequence of multivalent interactions mediated by the intrinsica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7271a72-de86-5f65-8dc2-4c1a28b3a333
DOI: 10.21203/rs.3.rs-4930444/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring Intrinsic Disorder in Stress Granules Proteome: Implications for Structure-Function Dynamics and Pathological AggregationDOI 10.21203/rs.3.rs-4930444/v1Read

Stress-Granules, P-bodies, and Cell Aging: A Bioinformatics StudySemantic proximity Read

Targeting stress granules in neurodegenerative diseases: A focus on biological function and dynamics disordersSemantic proximity Read

Stress Granules and Neurodegenerative Disorders: A Scoping ReviewSemantic proximity Read

Dr. Jekyll and Mr. Hyde? Physiology and Pathology of Neuronal Stress GranulesSemantic proximity Read

Stress granules regulate stress-induced paraspeckle assemblySemantic proximity Read

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress GranulesSemantic proximity Read

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stressSemantic proximity Read

Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?Semantic proximity Read

Unravelling biomolecular and community grammars of RNA granules via machine learningSemantic proximity Read

Role of stress granules and RNA-binding proteins in neurodegeneration: a mini-review.Semantic proximity Read

Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrumSemantic proximity Read

Stress-specific differences in assembly and composition of stress granules and related foci.Semantic proximity Read