Article

The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity

2025-12-17

Abstract excerpt

Runs of homozygosity (ROH) are contiguous genomic regions where all sites are homozygous, inherited from identical haplotypes due to shared ancestry. The number and length of ROH in individuals varies based on population history and sociocultural behaviors. Although often discussed in the context of inbreeding, ROH are ubiquitous in putatively outbred human pop-ulations, and their prevalence are associated with mu...

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Literature Corpus work: 47a55b75-811c-52be-9ad2-f2d48ac40148
DOI: 10.64898/2025.12.17.694908

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