Article

Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank

2020-10-27

Abstract excerpt

Runs of homozygosity (ROH) segments, contiguous homozygous regions in a genome were traditionally linked to families and inbred populations. However, a growing literature suggests that ROHs are ubiquitous in outbred populations. Still, most existing genetic studies of ROH in populations are limited to aggregated ROH content across the genome, which does not offer the resolution for mapping causal loci. This limita...

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Literature Corpus work: 17e76812-6545-5435-bfc5-53ed81eabdd5
DOI: 10.1101/2020.10.26.20220004

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