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Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations

2025-05-07

Abstract excerpt

Negative natural selection on deleterious mutations plays a key role in shaping human genetic variation. Understanding the dominance of deleterious mutations is critical as it can fundamentally impact the rate and efficiency of natural selection, the magnitude of inbreeding depression, and the prevalence and evolution of genetic diseases. Despite its inarguable importance, the dominance effects of mutations remain...

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Literature Corpus work
6d1bbedc-3938-5ac7-90ff-2e12ec98fda3
DOI
10.1101/2025.05.07.652751
Open publication

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Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutationsDOI 10.1101/2025.05.07.652751
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