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Long Runs of Homozygosity Are Correlated with Marriage Preferences across Global Population Samples

1 Jun 2021

Abstract excerpt

Children of consanguineous unions carry long runs of homozygosity (ROH) in their genomes, due to their parents' recent shared ancestry. This increases the burden of recessive disease in populations with high levels of consanguinity and has been heavily studied in some groups. However, there has been little investigation of the broader effect of consanguinity on patterns of genetic variation on a global scale....

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PMID: 37701498
DOI: 10.1353/hub.2021.0011

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