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Article

GARLIC: Genomic Autozygosity Regions Likelihood-based Inference and Classification.

Bioinformatics (Oxford, England) - 1 Jul 2017

Szpiech Zachary A, Blant Alexandra, Pemberton Trevor J

Abstract excerpt

SUMMARY: Runs of homozygosity (ROH) are important genomic features that manifest when identical-by-descent haplotypes are inherited from parents. Their length distributions and genomic locations are informative about population history and they are useful for mapping recessive loci contributing to both Mendelian and complex disease risk. Here, we present software implementing a model-based method ( Pemberton et...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28205676
DOI: 10.1093/bioinformatics/btx102
PMCID: PMC5870576

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