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Article

Adaptive Immunity and Parkinson's Disease.

Cold Spring Harbor perspectives in medicine - 1 Jul 2026

Elyaman Wassim

Abstract excerpt

Adaptive immunity plays a key role in the pathogenesis of Parkinson's disease (PD) and related conditions. This paper reviews the involvement of CD4+ and CD8+ T cells in PD development as well as the effect of PD genetic susceptibility variants and aging. Specifically, the major histocompatibility complex is associated with PD, influencing antigen presentation and, consequently, the T-cell receptor repertoire,...

Topics

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Adaptive Immunity
Aging
alpha-Synuclein
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
CD4 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Parkinson Disease

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Identifiers

PMID: 40523779
DOI: 10.1101/cshperspect.a041639
PMCID: PMC13322058

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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