Article
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
The Journal of clinical investigation - 1 Dec 1996
Wicker L S, Chen S L, Nepom G T, Elliott J F, Freed D C, Bansal A, Zheng S, Herman A, Lernmark A, Zaller D M, Peterson L B, Rothbard J B, Cummings R, Whiteley P J
Abstract excerpt
The identification of class II binding peptide epitopes from autoimmune disease-related antigens is an essential step in the development of antigen-specific immune modulation therapy. In the case of type 1 diabetes, T cell and B cell reactivity to the autoantigen glutamic acid decarboxylase 65 (GAD65) is associated with disease development in humans and in nonobese diabetic (NOD) mice. In this study, we identify...
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