Article
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
The Journal of clinical investigation - 1 Dec 1996
Wicker L S, Chen S L, Nepom G T, Elliott J F, Freed D C, Bansal A, Zheng S, Herman A, Lernmark A, Zaller D M, Peterson L B, Rothbard J B, Cummings R, Whiteley P J
Abstract excerpt
The identification of class II binding peptide epitopes from autoimmune disease-related antigens is an essential step in the development of antigen-specific immune modulation therapy. In the case of type 1 diabetes, T cell and B cell reactivity to the autoantigen glutamic acid decarboxylase 65 (G...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Autoantibodies
- B-Lymphocytes
- Cell Line
- Diabetes Mellitus, Type 1
- Epitopes
- Genes, MHC Class II
- Glutamate Decarboxylase
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans