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Article

Shared Epitope-Positive HLA Alleles Protect Against Alpha-Synuclein Pathology in a Model of Parkinson Disease.

Neurology(R) neuroimmunology & neuroinflammation - 1 May 2026

Carver Jonathan J, Pugh Bryce A, Ma Qin, Caillier Stacy J, Denbrock Rachael R, Martines Cindy C, Puckett Alexandra E, Roberson Taylor C, Fernandez-Viña Marcelo A, Hollenbach Jill A, Oksenberg Jorge, Holoshitz Joseph, Didonna Alessandro

Abstract excerpt

BACKGROUND AND OBJECTIVE: There is increasing evidence that human leukocyte antigen (HLA) allelic variants play a role in the genetic predisposition to Parkinson disease (PD). In this regard, we have recently reported that the HLA-DRB1*04:01 allele, typified by residues Q/R-K/R-R-A-A at positions 70-74 in the HLA-DRβ1 chain in combination with valine at position 11 (11-V), confers moderate protective effects. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41996655
DOI: 10.1212/NXI.0000000000200580
PMCID: PMC13095347

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