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Article

Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics.

The Journal of cell biology - 4 Aug 2025

Basello Davide A, Blažíková Michaela, Roithová Adriana, Hálová Martina, Radivojević Nenad, Neugebauer Karla M, Staněk David

Abstract excerpt

The Cajal body (CB) is a conserved non-membrane nuclear structure where several steps of small nuclear RNP particle (snRNP) biogenesis take place. It has been proposed that CB formation follows a liquid-liquid phase separation model, but this hypothesis has never been rigorously tested. Here, we applied live-cell imaging to show that the key CB assembly factor coilin is mobile within the CB, and we revealed a...

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Identifiers

PMID: 40560171
DOI: 10.1083/jcb.202309128
PMCID: PMC12189012

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