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Article

OCT4-MHC Tight Linkage in Mammals: A Comparative Evo-Devo, Immunogenomic, and Topological Framework

2026-07-14

Abstract excerpt

<h4>Background: </h4> The mammalian gene encoding OCT4, POU5F1, lies in or immediately adjacent to the major histocompatibility complex (MHC) region. In humans, POU5F1 is located at 6p21.33 within the extended HLA/MHC genomic neighborhood; in mice, Pou5f1 is on chromosome 17 within the homologous MHC-linked region. Marsupial data further suggest that this association belongs to an ancient mammalian immune supercom...

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Literature Corpus work
1e93be98-418f-59c8-a081-53909f54e65f
DOI
10.20944/preprints202607.0969.v1
Open publication

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OCT4-MHC Tight Linkage in Mammals: A Comparative Evo-Devo, Immunogenomic, and Topological FrameworkDOI 10.20944/preprints202607.0969.v1
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