Article

Spatial Proximity Sequencing Maps Developmental Dynamics in the Germinal Center

2025-10-28

Abstract excerpt

<h4>Summary</h4> Spatial profiling of proteins and protein interactions is essential for immunology, signaling, development, and cancer. We present Spatial Proximity-Sequencing (Sprox-seq), a multi-omic technique that simultaneously measures proteins, protein complexes and mRNAs, where location of each molecule is also recorded. Sprox-seq profiled 32 proteins, 528 pairwise protein interactions and thousands of mR...

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Literature Corpus work: ddab0b92-a463-5f38-8097-a71f4c9e8697
DOI: 10.1101/2025.10.27.684659

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