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Chromatin remodeling in bovine embryos indicates species-specific regulation of genome activation

17 Sept 2020

Abstract excerpt

The shift from maternal to embryonic control is a critical developmental milestone in preimplantation development. Widespread transcriptomic and epigenetic remodeling facilitate this transition from terminally differentiated gametes to totipotent blastomeres, but the identity of transcription factors (TF) and genomic elements regulating embryonic genome activation (EGA) are poorly defined. The timing of EGA is...

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PMID: 32943640
DOI: 10.1038/s41467-020-18508-3

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