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Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction

17 Mar 2020

Abstract excerpt

Adeno-associated virus (AAV) has been used extensively as a vector for gene therapy. Despite its widespread use, the mechanisms by which AAV enters the cell and is trafficked to the nucleus are poorly understood. In this study, we performed two pooled, genome-wide screens to identify positive and negative factors modulating AAV2 transduction. Genome-wide libraries directed against all human genes with four...

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PMID: 32280726
DOI: 10.1016/j.omtm.2020.03.012

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