Article
Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients.
Frontiers in immunology - 1 Jan 2023
Beltrán-García Jesús, Casabó-Vallés Germán, Osca-Verdegal Rebeca, Navarrete-López Paula, Rodriguez-Gimillo María, Nacher-Sendra Elena, Ferrando-Sánchez Carolina, García-López Eva, Pallardó Federico V, Carbonell Nieves, Mena-Mollá Salvador, García-Giménez José Luis
Abstract excerpt
Introduction: Sepsis patients experience a complex interplay of host pro- and anti-inflammatory processes which compromise the clinical outcome. Despite considering the latest clinical and scientific research, our comprehension of the immunosuppressive events in septic episodes remains incomplete. Additionally, a lack of data exists regarding the role of epigenetics in modulating immunosuppression, subsequently...
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