Article

Characterisation of the genetic determinants of context specific DNA methylation in primary monocytes

2023-05-19

Abstract excerpt

DNA methylation (DNAm) has pervasive effects on gene expression and associations with ageing-related traits. Here we describe monocyte DNAm responses to inflammatory stimuli across 192 individuals. We find that, unlike the similarly widespread changes in gene expression elicited by LPS and IFN γ , DNAm is markedly more sensitive to LPS. Exposure to LPS caused differential methylation at 20,858 immune-modulated Cp...

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Literature Corpus work: 564ceb90-a584-5e4c-8e9b-b4508252fe23
DOI: 10.1101/2023.05.17.541041

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