Article
A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.
Translational psychiatry - 6 Dec 2016
Cheng Y, Cawley N X, Yanik T, Murthy S R K, Liu C, Kasikci F, Abebe D, Loh Y P
Abstract excerpt
Patients with Alzheimer's disease (AD), a common dementia among the aging population, often also suffer from depression. This comorbidity is poorly understood. Although most forms of AD are not genetically inherited, we have identified a new human mutation in the carboxypeptidase E (CPE)/neurotrophic factor-α1 (NF-α1) gene from an AD patient that caused memory deficit and depressive-like behavior in transgenic...
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