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Article

Spatio-temporal dynamics and localization of MeCP2 and pathological mutants in living cells.

Epigenetics - 1 Sept 2007

Marchi Matilde, Guarda Alessia, Bergo Anna, Landsberger Nicoletta, Kilstrup-Nielsen Charlotte, Ratto Gian Michele, Costa Mario

Abstract excerpt

MECP2 is an X-linked gene coding for a protein functioning as a transcriptional repressor. The protein MeCP2 (Methyl CpG-binding protein) is an abundant component of pericentric heterochromatin and its mutations or duplications are present in around 80% of patients with a neurological disorder known as Rett Syndrome. Although MeCP2 action depends critically on its binding to chromatin, very little is known about...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17965612
DOI: 10.4161/epi.2.3.5057

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spatio-temporal dynamics and localization of MeCP2 and pathological mutants in living cells.PMID 17965612Read ↗

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