Article
MeCP2 links heterochromatin condensates and neurodevelopmental disease.
Nature - 1 Oct 2020
Li Charles H, Coffey Eliot L, Dall'Agnese Alessandra, Hannett Nancy M, Tang Xin, Henninger Jonathan E, Platt Jesse M, Oksuz Ozgur, Zamudio Alicia V, Afeyan Lena K, Schuijers Jurian, Liu X Shawn, Markoulaki Styliani, Lungjangwa Tenzin, LeRoy Gary, Svoboda Devon S, Wogram Emile, Lee Tong Ihn, Jaenisch Rudolf, Young Richard A
Abstract excerpt
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing1-3. Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Rett syndrome3-5, which is associated with severe mental disability and autism-like symptoms that affect girls during early childhood. Although previously thought to be a...
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