Article

Oncodrive3D: Fast and accurate detection of structural clusters of somatic mutations under positive selection

2025-01-14

Abstract excerpt

Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods that exploit different signals of positive selection in the pattern of mutations observed in genes across tumors have been developed to this end. One such signal of positive selection is clustering of mutations in areas of the three-dimensional (3D) structure of the prot...

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Literature Corpus work: 721a5d86-9133-5368-8397-06e3911865ed
DOI: 10.1101/2025.01.11.632354

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