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Article

mutation3D: Cancer Gene Prediction Through Atomic Clustering of Coding Variants in the Structural Proteome.

Human mutation - 1 May 2016

Meyer Michael J, Lapcevic Ryan, Romero Alfonso E, Yoon Mark, Das Jishnu, Beltrán Juan Felipe, Mort Matthew, Stenson Peter D, Cooper David N, Paccanaro Alberto, Yu Haiyuan

Abstract excerpt

A new algorithm and Web server, mutation3D (http://mutation3d.org), proposes driver genes in cancer by identifying clusters of amino acid substitutions within tertiary protein structures. We demonstrate the feasibility of using a 3D clustering approach to implicate proteins in cancer based on explorations of single proteins using the mutation3D Web interface. On a large scale, we show that clustering with...

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Identifiers

PMID: 26841357
DOI: 10.1002/humu.22963
PMCID: PMC4833594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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