Article

Protein structural context of cancer mutations reveals molecular mechanisms and identifies novel candidate driver genes

2024-03-26

Abstract excerpt

Advances in structure determination and computational modelling are enabling us to study the protein structural context of human genetic variants at an unprecedented scale. Here, we investigate millions of human cancer-associated missense mutations in terms of their structural locations and predicted perturbative effects. We find that, while cancer-driving mutations have properties similar to other known disease-c...

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Literature Corpus work: d7ebf3b1-3564-559e-b96b-75cb30778487
DOI: 10.1101/2024.03.21.586131

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