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The polyglutamine protein ATXN2: from its molecular functions to its involvement in disease

14 Jun 2024

Abstract excerpt

A CAG repeat sequence in the ATXN2 gene encodes a polyglutamine (polyQ) tract within the ataxin-2 (ATXN2) protein, showcasing a complex landscape of functions that have been progressively unveiled over recent decades. Despite significant progresses in the field, a comprehensive overview of the mechanisms governed by ATXN2 remains elusive. This multifaceted protein emerges as a key player in RNA metabolism, stress...

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PMID: 38877004
DOI: 10.1038/s41419-024-06812-5

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