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Article

Nuclear accumulation of mRNAs underlies G4C2 repeat-induced translational repression in a cellular model of <i>C9orf72</i> ALS

1 Jan 2015

Abstract excerpt

A common feature of non-coding repeat expansion disorders is the accumulation of RNA repeats as RNA foci in the nucleus and/or cytoplasm of affected cells. These RNA foci can be toxic because they sequester RNA-binding proteins, thus affecting various steps of post-transcriptional gene regulation. However, the precise step that is affected by C9orf72 GGGGCC (G4C2) repeat expansion, the major genetic cause of...

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PMID: 25788698
DOI: 10.1242/jcs.165332

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