Article

Bidirectional transcription at the <i>PPP2R2B</i> gene locus in spinocerebellar ataxia type 12

2023-04-03

Abstract excerpt

<h4>OBJECTIVE</h4> Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease caused by expansion of a CAG repeat in the PPP2R2B gene . Here we tested the hypothesis that the PPP2R2B antisense ( PPP2R2B-AS1 ) transcript containing a CUG repeat is expressed and contributes to SCA12 pathogenesis. <h4>METHODS</h4> Expression of PPP2R2B-AS1 transcript was detected in SCA12 human induced pluripotent s...

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Literature Corpus work: bcd38876-0fcd-5cc1-bd27-bcbffdd6bbd3
DOI: 10.1101/2023.04.02.535298

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