Article

Complement activation shapes immune contexture and immunotherapy response in clear cell renal cell carcinoma

2026-06-19

Abstract excerpt

<title>Abstract</title> <p> Clear cell renal cell carcinoma (ccRCC) tumors display strong yet functionally suppressed immune infiltrate, through mechanisms that remain poorly defined. The contribution of the complement system to this microenvironment is understudied, in part because complement activation cannot be inferred from most omics-based methods. Using our integrated complementomics approach combining spa...

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Literature Corpus work: 1e277b57-8797-5adf-b468-456b21f789f6
DOI: 10.21203/rs.3.rs-10060752/v1

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