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Enhanced Complement Expression in the Tumor Microenvironment Following Neoadjuvant Therapy: Implications for Immunomodulation and Survival in Pancreatic Ductal Adenocarcinoma

2023-10-30

Abstract excerpt

<h4>Purpose</h4> Neoadjuvant therapy (NAT) is increasingly being used for pancreatic ductal adenocarcinoma (PDAC) treatment. However, its distinct effects on carcinoma cells and the tumor microenvironment (TME) are not fully understood. This study employs spatial transcriptomics and single-cell RNA sequencing to investigate how NAT differentially remodels PDAC’s carcinoma cells and TME. <h4>Experimental Design</h...

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Literature Corpus work
e1d5bd18-28ce-5b79-aed4-6eb393ee4965
DOI
10.1101/2023.10.26.564099
Open publication

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