Back to search

Article

Tumor-infiltrating CD27 <sup>-</sup> IgD <sup>-</sup> regulatory B cells suppress cytotoxic CD8 <sup>+</sup> T cell responses in renal cell carcinoma

2025-07-12

Abstract excerpt

<h4>Summary</h4> B cells play a pivotal role in shaping the tumor microenvironment (TME) and tertiary lymphoid structures (TLS), but the functions of specific B cell subsets in cancer pathogenesis remain unclear. Using a novel tissue-centric single cell RNA-sequencing (scRNA-seq) bioinformatic workflow aimed at unraveling cancer-specific clusters, combined with flow cytometry and high-plex spatial imaging, we ide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1fba30ee-80d6-5ffb-bb1a-d42bd1b0dcd1
DOI
10.1101/2025.07.08.663720
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Tumor-infiltrating CD27 <sup>-</sup> IgD <sup>-</sup> regulatory B cells suppress cytotoxic CD8 <sup>+</sup> T cell responses in renal cell carcinomaDOI 10.1101/2025.07.08.663720
A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinomaSemantic proximity
Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinomaSemantic proximity
Multimodal cell communication networks nominate immunotherapies for RCC subgroups with discrete T cell recruitment or expansionSemantic proximity
Deconvolution of B-cell heterogeneity identifies PDIA6 as a prognostic driver in hepatocellular carcinomaSemantic proximity
Hallmarks of adaptive immunity in a metastatic clear cell renal cell carcinoma (ccRCC) long-term elite survivorSemantic proximity
The differentiation and functional landscape of tumor-resident CD8 <sup>+</sup> T cells shapes immunity and clinical outcomes in clear cell renal cell carcinomaSemantic proximity
Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinomaSemantic proximity
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell CarcinomaSemantic proximity
MDK promotes M2 macrophage polarization to remodel the tumour microenvironment in clear cell renal cell carcinomaSemantic proximity
The tumor necrosis superfamily member 4-1BBL expressed by tumor cells prevents exhaustion of CD8 T cells in a humanized mouse model of papillary renal cell carcinomaSemantic proximity
Transcriptome Profiling Reveals B-Lineage Cells Contribute to the Poor Prognosis and Metastasis of Clear Cell Renal Cell CarcinomaSemantic proximity
Deciphering Tumor Metastasis and Immune Inhibitory Signature of Clear Cell Renal Cell Carcinoma by Single-Cell Transcriptome AnalysisSemantic proximity
Select a neighboring publication to make it the new centre.