Complement activation drives a compartmentalized innate immune response in C3 glomerulopathy contributing to the disease phenotype.

doi:10.1016/j.kint.2025.12.009

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Article

Complement activation drives a compartmentalized innate immune response in C3 glomerulopathy contributing to the disease phenotype.

Kidney international - 1 Mar 2026

Meuleman Marie-Sophie, de Reyniès Aurélien, Mayinga Céline, Ngo Stéphanie, Rioux-Leclercq Nathalie, Vermorel Agathe, Olagne Jérome, Giovannini Diane, Francois Arnaud, Croué Anne, Planchard Gaëtane, Buob David, Delmas Yahsou, Courbebaisse Marie, Parfait Béatrice, Lebeaux David, Friedlander Gérard, Avramescu Marina, Brilland Benoit, Boulay Hugoline, Martins Manon, Roumenina Lubka, Frémeaux-Bacchi Véronique, Duong Van Huyen Jean-Paul, Chauvet Sophie

Abstract excerpt

INTRODUCTION: C3 glomerulopathy is a rare kidney disease resulting from dysregulation of the complement alternative pathway. The mechanistic diversity of alternative pathway activation, the heterogeneous immunological and clinical profiles limit a comprehensive understanding of the disease. METHODS: Here, we characterize mechanisms of complement-mediated immune response within the kidney. We studied a...

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PMID: 41443405
DOI: 10.1016/j.kint.2025.12.009

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