Article

Local, but not circulating, complement C3 governs immune checkpoint blockade efficacy

2025-05-13

Abstract excerpt

<h4>SUMMARY</h4> The roles of circulating complement C3, produced in hepatocytes, in immune defense are well defined in the literature. Interestingly, the C3 gene evolved before the circulatory system, suggesting an essential but yet unknown role of locally produced C3. Here, we investigated the effect of C3 on cancer immunotherapy and found that cancer-associated fibroblast (CAF)-derived C3, not hepatocyte-deriv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92e862be-0705-5de5-b30a-44d57a559245
DOI: 10.1101/2025.05.12.653608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Local, but not circulating, complement C3 governs immune checkpoint blockade efficacyDOI 10.1101/2025.05.12.653608Read

Local and Cell-intrinsic complement: The new player in cancer progressionSemantic proximity Read

Interplay between the complement system and other immune pathways in the tumor microenvironmentSemantic proximity Read

Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cellsSemantic proximity Read

The complement system as a target in cancer immunotherapySemantic proximity Read

Beyond the Norm: The emerging interplay of complement system and extracellular matrix in the tumor microenvironmentSemantic proximity Read

Complement activation shapes immune contexture and immunotherapy response in clear cell renal cell carcinomaSemantic proximity Read

Non-canonical extracellular complement pathways and the complosome paradigm in cancer: a scoping reviewSemantic proximity Read

Cancer and the Complement CascadeSemantic proximity Read

Early Neoplastic Progression Is Complement IndependentSemantic proximity Read

Prognostic and immune-related value of complement C1Q (C1QA, C1QB, and C1QC) in skin cutaneous melanomaSemantic proximity Read

Promotion of an Antitumor Immune Program by a Tumor Specific Complement Activating AutoantibodySemantic proximity Read

PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.Semantic proximity Read