Article
Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex.
Nature neuroscience - 1 Aug 2022
Gerrits Emma, Giannini Lucia A A, Brouwer Nieske, Melhem Shamiram, Seilhean Danielle, Le Ber Isabelle, Kamermans Alwin, Kooij Gijs, de Vries Helga E, Boddeke Erik W G M, Seelaar Harro, van Swieten John C, Eggen Bart J L
Abstract excerpt
Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia, affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the progranulin gene (GRN) cause autosomal-dominant FTD (FTD-GRN), associated with TDP-43 inclusions, neuronal loss, axonal degeneration and gliosis, but FTD-GRN pathogenesis is largely unresolved. Here we report single-nucleus RNA...
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