Article

Progranulin haploinsufficiency remodels the cerebral microvasculature and neurovascular unit

2026-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Progranulin (PGRN) deficiency is a major genetic cause of frontotemporal dementia (FTD), yet its impact on cerebrovascular function remains understudied. Here, we show that PGRN deficiency contributes to cerebral microvascular perfusion and induces alterations within the neurovascular unit. In vivo two-photon imaging revealed increased capillary stalling and in cerebral blood flow (CBF), driven...

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Literature Corpus work: 6a266744-9ef8-502b-bef1-c2d7e9254654
DOI: 10.64898/2026.07.20.738719

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