A metabolomic signature of the APOE2 allele.

doi:10.1007/s11357-022-00646-9

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Article

A metabolomic signature of the APOE2 allele.

GeroScience - 1 Feb 2023

Sebastiani Paola, Song Zeyuan, Ellis Dylan, Tian Qu, Schwaiger-Haber Michaela, Stancliffe Ethan, Lustgarten Michael S, Funk Cory C, Baloni Priyanka, Yao Cong-Hui, Joshi Shakchhi, Marron Megan M, Gurinovich Anastasia, Li Mengze, Leshchyk Anastasia, Xiang Qingyan, Andersen Stacy L, Feitosa Mary F, Ukraintseva Svetlana, Soerensen Mette, Fiehn Oliver, Ordovas Jose M, Haigis Marcia, Monti Stefano, Barzilai Nir, Milman Sofiya, Ferrucci Luigi, Rappaport Noa, Patti Gary J, Perls Thomas T

Abstract excerpt

With the goal of identifying metabolites that significantly correlate with the protective e2 allele of the apolipoprotein E (APOE) gene, we established a consortium of five studies of healthy aging and extreme human longevity with 3545 participants. This consortium includes the New England Centenarian Study, the Baltimore Longitudinal Study of Aging, the Arivale study, the Longevity Genes Project/LonGenity...

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PMID: 35997888
DOI: 10.1007/s11357-022-00646-9
PMCID: PMC9886693

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APOE

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